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KMID : 1101420210530010088
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Korean Journal of Clinical Laboratory Science
2021 Volume.53 No. 1 p.88 ~ p.95
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Effects of Aucklandia lappa Decne. Extract on Hair Growth in Depilated CL57BL/6 Mice
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Kim Joung-Hee
Lee Syng-Ook
Beik Gyoung-Yeun
Kim Keuk-Jun
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Abstract
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Aucklandia lappa Decne., a traditional herbal medicine, has been used to treat various diseases, including asthma, coughs, rheumatism, and diarrhea. In the present study, the effects of the oral administration of Aucklandia lappa Decne. extract on hair growth was investigated in hair-removed mice. A 70% ethanol extract of Aucklandia lappa Decne. (ALD) was prepared, and the extraction yield and total polyphenol content of ALD were measured as 27.30±0.01 and 28.39 mg gallic acid equivalent (GAE)/g, respectively. The oral administration of ALD to hair-removed CL57BL/6 mice for six weeks had no significant effects on food intake and body weight changes. Biochemical and histological examinations also showed that the oral administration of ALD for six weeks had no significant effect on the liver and kidney functions. On the other hand, hair growth was significantly higher in the ALD group than the control group and the Pancidil group (positive control). In addition, the number of hair follicles and the degree of collagen production in the dermis were significantly higher in the ALD group than in the control and pancidil groups. These results suggest that ALD is a potential source of nutricosmetics with hair growth-promoting effects.
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KEYWORD
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Aucklandia lappa Decne., CL57BL/6 mouse, Collagen, Hair growth, Oral administration
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